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.: Дата публікації 2009-06-25 :: Переглядів: 8 ::  :.
Clinical-hemodynamic and inflammatory-neuroautoimmune connections in acute ischemic stroke
T.M. CHERENKO
Purpose — to study dependence of inflammatory- neuroautoimmune processes, cerebral blood flow and consequences of cerebral stroke in acute period.
Methods and subjects. Examination of 48 patients aged 56–68 years (average 62 ± 3.4 years) in acute period of ischemic stroke was carried out. The content of ІL-6, TNF-?, ІL-4, C-reactive protein (CRP) and markers of neuroautosensibilisation and linear speed of cerebral blood flow (LSCBF) were determined.
Results. The strongest correlations of all inflammatory markers were found for CRP and neuroautosensibilisation indexes: NSE, S-100В, and their antibody, (r = 0.81–0.71). The least correlations were found between TNF-?, and neuroautosensibilisation indexes (r = 0.43–0.61). Decreasing of concentration of IL-6 and increasing of LSCBF in examined vessels areas were inversely correlated with neurological deficit on the 21-st day for all compared pairs. The same regularity was notified in increasing of concentration ІL-4, decreasing NSE, CRP, anti-S-100 antibody and increasing of LSCBF in all blood areas.
Conclusions. The connection between increasing of cerebral blood flow and decreasing inflammatory- neuroautosensibilisation processes has been found. Also it was detected between other indexes and stroke outcome: decreasing of inflammatory marker or neuroautosensibilisation processes and synchronous increasing of LSCBF.That testifies the improvement of neurological functions on 21-st day.
Ключові слова: inflammatory markers, neuroautosensibilisation, correlations, cerebral blood flow, neurological deficit.
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