.: Дата публікації 2009-07-14 :: Переглядів: 8 :: 
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Сircadian heart rate variability after ischemic insult in patients with arterial hypertension, ischemic heart disease, and diabetes mellitus of 2 type
V.Z. NETIAZHENKO, T.J. MALCHEVSKA
The purpose — to study the circadian heart rate variability after ischemic insult in hypertensive patients with ischemic heart disease and associated diabetes mellitus (DM) of II type.
Materials and methods. 45 patients were examined during first days after their hospitalization into the endocrinologic and cardiac department. All patients were distributed into 3 groups: the 1st (20 patients) included patients with IHD with hypertension and DM of the II type; the 2nd group (10 patients) included hypertensive patients with DM of II type; the 3rd (15 patients) group included patients who underwent IHD from 1 to 5 years ago. The ECG Holter monitoring with subsequent calculation of generally accepted heart rate variability indices and arterial pressure monitoring were performed in all groups.
Results. The disorder of vegetative balance was observed in all patients. The analysis established different changes in heart rate variability according to the different degree of lowering of night blood pressure in patients (pts) with IHD associated hypertension and diabetes mellitus of II type. The absence of marked daily variability of the most indexes demonstrated the rigidity of vegetative heart rate. The circadian is the sign of the vegetative denervation. The circadian indices characterizing the parasympathetic and sympathetic activity were equally lower at nigh time in group pts with stroke.
Conclusions. In affecting of two vessels regions — cerebral and coronary — the lowering of heart rate variability is observed in hypertensive patients with DM of 2 type. The absence of daily heart rate variation with vegetative denervation and rigidity of the vegetative heart rate allows to explain the lowering of circadian rate and occurrence of cerebral insults in this patient category.
Ключові слова: ischemic heart disease, ischemic insult, arterial hypertension, diabetes mellitus of 2 type, daily rate, heart rate variability.
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