1-2007

.: Дата публікації 2009-07-16 :: Переглядів: 8 :: :.

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Intrasystemic relationships of cerebral hemodynamics in subjects with high environmental and genetic risks for cerebro-vascular pathology development: age peculiarities
V.V. KUZNETSOV, E.P. KRASYLENKO

Purpose — the comparative analysis of age structure of various levels cerebral hemodynamics correlation at the persons with high ecological and genetic risk of cerebro-vascular system pathology development.
Methods and subjects. The condition of cerebral hemodymanics was studied in 97 Chernobyl accident liquidators aged 30 to 69 years with mild cerebro-vascular pathology, 58 first degree kinship relatives of ischemic stroke patients (RISP), intact to radiation factor, and 65 radiation intact control subjects without cerebro-vascular pathology (C). The method of extra- and transcranial ultrasound dopplerography was used.
Results. With aging, the intrasystemic correlations of cerebral hemodynamics are enhanced. The enhancement of correlations between the linear systolic blood flow velocity (LSBFV) in the carotic extra- and intracranial arteries occurred 10 years earlier in liquidators(at the age of 30—39 years) in comparison to the group with a hereditary disposition to stroke (at the age of 40—49 years) and 30 years earlier than in C subjects group (at the age of 60—69 years).
The liquidators have age changes of the correlations between hemodynamic indices in the vertebro-basilar (VB) area simultaneously with those observed in RISP (at the age of 30—39 years) and two decades earlier than in C group subjects (at the age of 50—59 years). The correlations between LSBFV in the homolateral intracranial links of carotid and VB areas of the liquidators were formed in the average 10 years earlier (at the age of 30—39 years) and versus RISP (at the age of 40—49 years), whereas in C group subjects the range of regulation of correlations between hemodynamic indices in the carotid and VB areas remained wide enough at all investigated age periods. The results indicate the varying tempo of age changes of the cerebral blood flow regulation in three groups. The most severe intrasystematic cerebral hemodynamic correlations have been detected in radiation intact relatives of ischemic stroke patients aged 40—59, whereas liquidators have these correlations at the age of 30—59.
Conclusions. Obtained results are the evidence of deregulating influence of genetic factor and radiation factors on the systematic regulation of cerebral hemodynamic.