.: Дата публікації 2009-07-16 :: Переглядів: 8 :: 
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Application of antihomotoxic therapy in patients with disseminated sclerosis with herpes viral persistency
L.I. SOKOLOVA, A.A. KRUGLIAK
Purpose: to determine antihomotoxic medications efficiency under the treatment of patients with disseminated sclerosis (DS) with herpes viral persistency.
Materials and methods. Examination of 20 patients with disseminated sclerosis with herpes viral persistency at the age from 20 till 48 has been carried out. In addition to neurological examination and determination of function disorder stage by the Expended Disability Status Scale (EDSS), immunologic, serologic and immunobiologic blood examinations for virus in dynamic before and after the treatment have been carried out. During 20 days antihomotoxic medications were prescribed to patients.
Results. Against the background of herpes viral persistency at the moment of examination IgМ was determined in 7 patients, three of them had virus DNA. 12 patients had increased captioning data of IgG. Antiviral therapy with inactive phase was prescribed to 3 patients, but they had a side effect. Treatment with antihomotoxic medications didn't cause any unfavourable symptoms in none of the patients. After the treatment the average stage of disability according to EDSS has declined to 2,63 (for 0,3 marks). The average level of IgG to HHV-6 has declined by a factor of 1,7, to EBV - by a factor of 1,5, polymerase chain reaction has become negative. Number of B-cells has declined to the level of scheduled figures, indexes of antibody-dependent cytotoxicity have increased, but haven't reached the scheduled figures level. The level of circulatory immune complexes and autoantibody concentration to the main protein myeline has declined notably.
Conclusions. The prescription of antihomotoxic medications is considered to be expedient in case of the necessity of prolonged viral persistency control in patients with DS after antriviral medications treatment or under accomplished somatical pathology.
Ключові слова: disseminated sclerosis, herpes viral persistency, antihomotoxic medications.
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